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Huntington’s disease affects an estimated 2.7 every 100,000 individuals The rising prevalence fosters demand for research and treatment management of huntington’s disease.
Huntington’s disease (HD) is an inherited condition where specific brain cells gradually break down, impacting movement control and various aspects of behavior and emotion. Individuals with huntington’s disease (HD) may experience involuntary dance-like movements called chorea, which can intensify when nervous or distracted. Symptoms typically emerge in middle-aged adults but can also affect children, albeit rarely. The disease progresses, leading to increased movement, balance and cognitive function challenges. In the early stages, signs may manifest as mild clumsiness, balance issues or cognitive and emotional difficulties. Some may face difficulties walking due to chorea, while others might become rigid or experience unusual, fixed postures, known as dystonia. Tremors, abnormal eye movements, slurred speech and problems with swallowing and eating are common physical changes. As HD advances, individuals may face weight loss, fatigue, seizures and eventually require assistance with mobility. Cognitive changes include issues with attention, judgment, decision-making and organizing tasks. Severe cognitive impairment may lead to dementia, hindering daily functioning. Despite these challenges, many people with huntington’s disease (HD) remain aware of their surroundings and can express emotions. Behavioral changes encompass mood swings, irritability, apathy, depression and anger, with some individuals experiencing persistent symptoms like suicidal thoughts and psychosis. Social withdrawal can occur, impacting participation in activities. It is essential to approach HD with empathy, recognizing it as a severe condition requiring comprehensive management. The global demand for effective treatments has increased as awareness of this challenging disorder grows.
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