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Report Highlights:

• Arthritis, an inflammatory bone disorder remains the most prevalent target capturing 38% of the market share in 2023.
• The oral route of administration reigns supreme with a 56% market share in 2023 due to its convenience.
• Retail pharmacies lead the pack with a commanding 46% market share in 2023.
• North America leads the way in the NSAIDs market.

The Centers for Disease Control and Prevention reports roughly 1 in 5 adults in the U.S., around 53.2 million people, have arthritis. It’s more common in women (20.9%) than men (16.3%). Nonsteroidal anti-inflammatory drugs are highly recommended for managing the pain.

Non-steroidal anti-inflammatory drugs are commonly used to relieve pain, reduce inflammation, and lower fever. They are widely used to treat arthritis, muscle aches, headaches, menstrual cramps, and minor injuries like sprains and strains. NSAIDs block the production of chemicals in the body called prostaglandins, which are responsible for pain and inflammation.

These medications are often found in over-the-counter forms like ibuprofen (Advil, Motrin), naproxen (Aleve), and prescription-strength versions. NSAIDs are usually available in oral form, but some can be applied topically as creams or gels for localized pain relief.

Growing Concerns Over Opioid Addiction Are Leading People to Seek Safer Pain Management Options

Worries about opioid addiction and misuse have prompted many individuals to look for safer alternatives to manage their pain. This shift has resulted in an increase in the use of non-opioid options, particularly non-steroidal anti-inflammatory drugs (NSAIDs). Unlike opioids, which can be highly addictive and come with serious side effects, NSAIDs provide effective pain relief with a much lower risk of addiction.

NSAIDs work by reducing inflammation and blocking pain signals, making them a popular choice for conditions like arthritis, headaches, and muscle strains. Many people, along with healthcare providers, favor these medications because they are generally effective and have fewer side effects.

One of the key factors contributing to the rise in NSAID use is their accessibility. These medications are available over-the-counter at pharmacies and grocery stores, allowing consumers to easily purchase them without needing a prescription. This convenience has further fueled the growing demand for NSAIDs. Beyond medical settings, more people are turning to over-the-counter NSAID products for quick relief from everyday aches and pains. This trend reflects a broader cultural shift toward being more mindful of the risks associated with opioids and a preference for safer pain relief options.

Healthcare professionals are increasingly recommending NSAIDs as a first-line treatment for pain management, thanks to their established safety and effectiveness. This endorsement has contributed to the rising popularity of NSAIDs among various patient groups.

Overall, the increasing preference for non-opioid pain management options like NSAIDs stems from concerns about opioid addiction, combined with the effectiveness, accessibility, and safety of these medications. As a result, NSAIDs have become essential tools for managing pain and enhancing quality of life in both medical and consumer contexts.

Significant Advances in Non-steroidal Anti-inflammatory Drug Development

Recent advancements in drug delivery technologies have significantly changed how NSAIDs are administered and used. One notable innovation is the development of topical NSAID formulations—creams, gels, or patches that are applied directly to the skin over the painful area. This targeted approach allows the medication to be absorbed through the skin, directly addressing the source of pain or inflammation. It enhances the effectiveness of NSAIDs while minimizing systemic side effects.

Another important development is the creation of sustained-release NSAID formulations. Unlike traditional immediate-release NSAIDs, which provide quick but short-lived relief, sustained-release versions gradually release the medication over an extended period. This method ensures a consistent level of NSAID in the bloodstream, resulting in longer-lasting pain relief and reducing the number of doses needed throughout the day.

With many companies involved in the research, production, and marketing of NSAIDs, there has been a push for both organic and inorganic growth strategies to strengthen their market presence. For example:

• In August 2021, Alkem Labs launched ibuprofen and famotidine tablets in the U.S. after receiving approval from the FDA.
• In September 2020, Dr. Reddy’s Laboratories introduced diclofenac sodium topical gel (1%) over the counter, aimed at relieving arthritis pain in the U.S.

These innovations in drug delivery technology come with several benefits. Topical NSAID formulations allow for localized pain relief without systemic absorption, which helps reduce the gastrointestinal side effects often associated with oral NSAIDs. They also offer convenience, enabling patients to apply the medication directly to the affected area as needed.

Sustained-release NSAIDs improve patient compliance by requiring less frequent dosing than immediate-release options. They provide consistent pain relief over an extended period, enhancing patient comfort and quality of life.

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