The recombinant lysyl endopeptidase market was valued at approximately $38 million in 2023 and is projected to reach $67.06 million by 2034, representing a compound annual growth rate (CAGR) of 5.3% from 2024 to 2034. This growth is driven by the increasing demand for proteomics and genetic engineering, rising investments in research and development, and the growing prevalence of chronic illnesses.
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Recombinant lysyl endopeptidase is an enzyme that cleaves amide and peptide ester bonds at the carboxylic side of lysine and S-aminoethyl cysteine residues. It is primarily sourced from three microorganisms: Achromobacter, Lysobacterium, and Pseudomonas aeruginosa. The natural form of this enzyme faces limitations due to low yield, complex purification processes, and lengthy production cycles. However, the recombinant variant overcomes these challenges, resulting in higher yields and improved purification.
This enzyme finds extensive applications in various fields, including proteomics, peptide sequencing, insulin preparation, identification of phosphorylated peptides, disulfide bond analysis, N-glycan analysis, and the detection of glycated hemoglobin. The growing emphasis on research and development, along with increasing investments in R&D, is driving the market. Areas such as proteomics, genetic engineering, and personalized medicine are significantly boosting the demand for recombinant lysyl endopeptidase. Moreover, the rising prevalence of diabetes is escalating the need for insulin, further propelling market growth.
In September 2024, Sino Biological, a prominent company in recombinant protein production, announced a strategic partnership with BioGeometry, an innovator in generative AI for protein design. This collaboration aims to enhance Sino Biological’s protein expression and wet lab capabilities by integrating BioGeometry’s AI-driven protein design and optimization platform.
Additionally, the Chinese Government recently established the π-HuB Consortium to invest in new proteomic technologies, focusing on single-cell proteomics and protein sequencing. This initiative aims to develop computational models and tools for disease risk assessment, diagnosis, and treatment guidance.
Proteomics encompasses the comprehensive study of protein functions, interactions, composition, and structures to gain insights into the nature of organisms. It plays a crucial role in identifying various proteins and targets associated with diseases, making it vital for novel drug discovery and the identification of disease biomarkers. Proteomics also sheds light on protein-protein interactions, which are essential for understanding cell signaling cascades and gene regulatory networks. As recombinant lysyl endopeptidase is a critical enzyme in proteomics research, the rising incidence of chronic disorders and the demand for innovative drug development, diagnostics, and early disease detection are driving the need for proteomics. Consequently, this surge in interest translates into increased demand for recombinant lysyl endopeptidase.
Despite its potential, the high cost of recombinant lysyl endopeptidase poses a significant barrier to market growth. The average price of this recombinant protein ranges from $350 to $500 for 20 μg, limiting its accessibility for many laboratories and research institutions, particularly in lower- and middle-income countries.
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