Resorbable Nerve Conduits Market Insights
The global resorbable nerve conduits market size was estimated at US$ 2.31 billion in 2023 and is projected to grow to US$ 5.28 billion by 2034, rising at a compound annual growth rate (CAGR) of 7.8% from 2024 to 2034. The rising demand to treat nerve injuries by reducing the risk of inflammation and regenerating nerve with the presence of foreign body is increasing the adoption of resorbable nerve conduit market.
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Market Overview
Resorbable nerve conduit devices may be derived from natural or synthetic materials. Utilization of a resorbable PGA (polyglycolic acid) tube filled with collagen sponge restores both sensory and motor electrophysiological functions. This technique is also considered superior to an autograft technique. The combination of a resorbable synthetic tube with biological factors leads the way in advancing the future. This strategy encourages and hastens nerve growth. The incorporation of several neurotrophic factors has demonstrated the capability to promote axonal growth in vitro. However, its use in vivo is still undiscovered.
Resorbable Nerve Conduits Market Trends
- In September 2024, the US Food and Drug Administration (FDA) granted breakthrough therapy designation (BTD) to Neuraptive Therapeutics Inc.’s NTX-001 for the treatment of patients with peripheral nerve injury requiring repair. The BTD is awarded on the promising result of the Phase II NEUROFUSE study and as per US regulations.
- In January 2024, Nalu Medical, a privately held commercial medical device company, announced $65 million in equity financing to support their minimal invasive neurostimulation product. The company has received FDA approval for spinal cord stimulation and peripheral nerve stimulation technology to treat patients with chronic neuropathic pain.
Emerging Biomaterial: Opportunity of Resorbable Nerve Conduits Market
The innovation of biodegradable nanomaterial is expected to be beneficial for manufacturing new nerve conduits. Combining an adequate density and 3D structure to design a scaffold with Schwann Cells can replicate Bands of Büngner to enhance the regrowth of axons in the peripheral nerve injury. To eliminate the immune rejection. Schwann Cells can be withdrawn from either umbilical stem cells or other tissues such as autologous adipose tissue. This collaboration application of tissue, cell and genetic engineering can provide promising results in better functional recovery of peripheral nerve injury.
Segmental Insights
- By Material: The synthetic polymer segment led the resorbable nerve conduits market in 2023, largely due to the advantages offered by synthetic materials in creating devices for peripheral nerve injury. These materials are readily available and can be engineered to adjust their physical and mechanical properties, such as strength, permeability, and degradation rates, which contributes to market growth.
- The natural polymer segment is expected to grow the fastest during the forecast period. This growth is driven by the ability of natural polymers to eliminate the need for a second surgery to remove the implant and reduce the long-term compression of the nerve. Commonly used natural polymers include laminin, fibronectin, and collagen.
- By Application: The peripheral nerve repair segment was the market leader in 2023. This dominance stems from the popularity of resorbable nerve conduits in repairing peripheral nerves. These conduits are easy to apply and don’t require a donor site, making them a preferred choice for bridging nerve gaps.
- The spinal cord repair segment is expected to experience notable growth during the forecast period. Spinal cord injuries are repaired by promoting axonal regeneration and providing a protective environment for neurons. Researchers are working to improve nerve cell regeneration and enhance the function of remaining nerve cells after a spinal injury through the use of prostheses and medicines.
- By Conduit Design: The multi-lumen conduits segment was the largest in 2023. These conduits support the regeneration of peripheral nerves by bridging gaps of up to 10 mm. They also have the ability to control the release of neurotrophic factors during the regeneration process. Multi-lumen conduits are more advantageous than other types because they closely mimic the natural structure of nerves.
- The branch conduit segment is expected to grow the fastest during the forecast period. This growth is due to the ability to customize branch nerve conduits using 3D printing technology, allowing for tailored shapes and the addition of active cells.
- By Mechanism of Action: The neurotrophic conduit segment held the largest market share in 2023. Neurotrophic factors, which are polypeptide systems that support cell survival, are crucial for regenerating motor and sensory neurons both in vivo and in vitro.
- The glial conduit segment is expected to see the fastest growth during the forecast period. This growth is linked to the regeneration of axons, as glial conduits provide a supportive environment for nerve regeneration.
- By Regeneration Level: The complete regeneration segment dominated the market in 2023. This segment is driven by advancements in nerve repair techniques that enable the successful recovery of nerve injuries, helping patients regain sensory functions and movement.
- The partial regeneration segment is expected to grow significantly during the forecast period. Partial regeneration occurs when nerve recovery is slow, with a rate of about 1 millimeter per day or 1 inch per month, leading to less satisfactory outcomes for patients.
Top Companies in the Resorbable Nerve Conduits Market
- AxoGen
- Integra Lifesciences
- Boston Scientific Corp.
- Medtronic
- Baxter
- Regenity Bioscience
- NEUROMetrix
- Toyobo
- Checkpoint Surgical
- Orthomed
- SIA
- Alafair
- Abbott
- Synapse
- KeriMedical
- Nevro
- Ortho Cell
- Epineuron
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