Gene Synthesis Service Market Size, Trends & Growth Forecast
The gene synthesis service market, valued at approximately USD 585 million in 2023, is expected to expand significantly, reaching USD 3,138.64 million by 2034 with a projected compound annual growth rate (CAGR) of 16.5% from 2024 to 2034. Market growth is driven by the rising prevalence of chronic disorders, increasing demand for genomic solutions, and robust research and development initiatives.
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Gene Synthesis Service Market: Genomic Innovations
Gene synthesis is the process of chemically synthesizing a strand of DNA, RNA, and other oligonucleotides base-by-base. A DNA sequence can be synthesized, including sequences that do not exist in nature or generate variants of naturally occurring sequences. Researchers employ synthetic genes to investigate a wide range of biological functions that nucleic acids perform, including mediating cell-cell communications, encoding proteins, controlling gene expression in the nucleus, and forming biofilms from extracellular DNA. Gene synthesis services refer to providing custom-cloned gene sequences for optimal protein expression. The services save researchers time and allow researchers to focus on functional studies.
The rising incidences of chronic disorders like cancer and viral and infectious diseases drive the market. Gene synthesis techniques are used to engineer, detect, and identify genomes of these disorders. Also, newly identified viral genomes can be synthesized for vaccine development. Additionally, the growing research and development activities and increasing investments in biotechnology boost the market.
Gene Synthesis Service Market Trends
- In January 2024, Twist Bioscience Corporation announced the expansion of Twist Express Genes, a new leading gene synthesis service including larger DNA preparations of up to 1 milligram. They offer rapid gene synthesis at all gene prep scales for pharmaceutical, biotechnology, academic, and industrial chemical researchers.
- In December 2023, Evonetix Ltd., the company developing semiconductor scale technology to improve access to gene synthesis, announced the signing of a joint development agreement and commercial supply agreement with Analog Devices, Inc.
- In January 2024, Elegen announced a collaboration and licensing agreement with GSK to use Elegen’s proprietary cell-free DNA manufacturing technology to develop GSK’s vaccines and medicines. The agreement provides Elegen with up to $35 million in near-term financial and development support and fees and a potential equity investment by GSK.
Growing R&D Fuels Opportunities in the Gene Synthesis Service Market
The rising demand for vaccine development, cancer immunotherapy, and gene therapy has spurred research and development in gene synthesis. The increasing prevalence of cancer and viral infections is further expanding the market, with cancer treatment and vaccine development emerging as key global research priorities. The need for rapid research outcomes is driving demand for gene synthesis services, leading many pharmaceutical and biotechnology companies to partner with gene synthesis providers. These collaborations streamline research workflows, enabling more accurate and timely results. Gene synthesis is instrumental in producing antibodies, recombinant proteins, and ELISA assay kits, while advancements in gene therapy are accelerating market growth. Synthetic genes can replace defective genes or introduce new functions into cells, supporting the development of custom, high-quality DNA sequences. Companies are investing heavily in R&D to foster sustainable growth, strengthen their global footprint, and maintain technological leadership.
Challenges: Quality Assurance and High Costs in the Gene Synthesis Service Market
Maintaining quality and reliability in both the gene synthesis process and end products presents a significant challenge to the market. Quality issues such as synthesis errors, sequence discrepancies, or contamination can hinder reproducibility, limiting the applicability of gene synthesis in commercial settings. High initial costs for gene synthesis services also pose a barrier, as providers require advanced infrastructure and specialized equipment.
Regional Insights: North America’s Leading Position with Rising Investments
North America led the gene synthesis service market in 2023, driven by state-of-the-art research facilities, increasing investments, and the presence of major industry players. The US and Canada, with their advanced pharmaceutical and biotechnology sectors, are central to this growth. In 2021, biotechnology R&D made up 17% of total US business R&D. The US houses many of the leading gene synthesis companies, contributing significantly to global revenue. In Canada, govenment investments in biomanufacturing, including $1.2 billion in 2021 and an additional $40 million in 2024 by Ontario’s government to support local life sciences firms, are reinforcing the market’s foundation and growth trajectory.
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