Molecular diagnostics has emerged as a sensitive and largely accurate method for early detection of infectious diseases, with significant applications in improving patient outcomes. The COVID-19 pandemic accelerated the adoption of such methods due to the crucial need for early disease detection. These diagnostics offer the advantage of detecting biomarkers at very low concentrations, enabling early diagnosis. They are also affordable and can be conducted at the point of care. Detection methods include DNA sequencing, microarrays, fluorescent probes, and Fluorescence In-Situ Hybridization.
One significant challenge in early diagnosis is faced by infants born to HIV-positive mothers. Maternal antibodies crossing the placenta can interfere with antibody-based HIV tests for up to 18 months, delaying definitive diagnosis. However, qualitative nucleic acid testing has become the predominant method for identifying HIV infection in young infants. These assays directly identify viral components such as HIV pro-viral DNA or RNA, avoiding the problem of maternal antibodies. For example, the COBAS AmpliPrep/COBAS TaqMan HIV-1 Qualitative Test requires only 70 µl of whole blood or a dry blood spot and accurately detects specific sections (gag and LTR) of the HIV-1 genome.
Successful treatment and improved patient survival rates are significantly possible with molecular diagnostics. Diagnostic biomarkers enable the identification of diseases at the earliest possible stage, facilitating reliable treatment initiation. The demand for early identification of cancer and infectious disorders is driving the need for more efficient molecular diagnostic techniques.
In 2020, a WHO-recommended rapid molecular test was utilized as the initial diagnostic test for 1.9 million (33%) of the 5.8 million people newly diagnosed with tuberculosis globally, up from 28% in 2019. There was significant diversity across countries, with the largest percentages attained in the WHO African and European regions. Globally, 73% of the 5.8 million people newly diagnosed with tuberculosis had a recorded HIV test result, up from 70% in 2019.
The growing need for early disease detection is stimulating research and development efforts for innovative tests capable of detecting diseases earlier and more accurately. The market is witnessing an increase in the usage of these new tests in various healthcare settings, from specialized cancer centers to ordinary clinical practices.
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Molecular diagnostics has revolutionized healthcare by enabling precise and sensitive disease diagnosis at the molecular level. Recent innovations are propelling this sector forward, resulting in substantial growth in the molecular diagnostics market. Here’s an overview of major advancements and their impact:
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Cancer and infectious diseases pose significant threats to global health. According to the World Health Organization (WHO), cancer is the second leading cause of death worldwide, while infectious diseases continue to cause morbidity and mortality, particularly in low-income countries.
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The increasing demand for early cancer and infectious disease detection is driving the growth of the molecular diagnostics market. As demand for accurate and rapid diagnosis continues to rise, further advancements in molecular testing technology are expected to revolutionize healthcare approaches to these challenging health conditions.
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