The global oligonucleotide synthesis market is projected to grow from an estimated US$ 5.59 billion in 2024 to US$ 20.31 billion by 2034, reflecting a compound annual growth rate (CAGR) of 13.78%. This growth is primarily driven by the increasing demand within the biotechnology sector.
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Oligonucleotide synthesis involves the precise joining of nucleotides to create specific sequences. Typically, packed-bed columns are used in continuous solid-phase synthesis, while batch slurry reactions may be employed in some scenarios. Oligonucleotides serve as sequence-specific binding agents in various biological and forensic applications to detect target DNA sequences. Modified oligos have been crucial in numerous life science applications, especially in molecular diagnostics and therapeutic contexts.
Artificial intelligence (AI) plays a pivotal role in the development and modification of therapeutic oligonucleotides. For instance, Sylentis utilizes its sirFinder program, which employs sophisticated algorithms to analyze extensive datasets and predict the effectiveness of synthesized oligonucleotides. Such tools enhance the precision and speed of gene therapy development.
Noteworthy Example: In March 2022, Creyon Bio raised $40 million in a Series A funding round led by DCVC Bio and Lux Capital, aiming to develop precision medications using machine learning to design treatments for both individual patients and larger populations.
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