The global peptide synthesis market is poised for significant growth, driven by advancements in technology, an increasing demand for peptide-based therapeutics, and the growing need for precise and efficient drug development processes. In 2024, the market size is calculated at USD 686.59 million and is projected to grow to USD 774.06 million in 2025, continuing to expand at a robust CAGR of 12.74% between 2025 and 2034. By 2034, the market is expected to reach around USD 2277.59 million. This expansion is primarily driven by rising incidences of chronic disorders, growing research and development activities, and continuous technological advancements in peptide synthesis techniques.
The market is diverse, with various segments exhibiting different growth patterns and trends. This article delves into the key segments of the peptide synthesis market, highlighting their dominance, growth potential, and recent innovations.
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In 2023, the reagents & consumables segment held a dominant presence in the peptide synthesis market. Reagents and consumables are essential for the peptide synthesis process, providing the necessary building blocks for creating peptides. These include amino acids, coupling reagents, protecting reagents, chelators, resins, and other critical components that facilitate the synthesis. The use of reagents and consumables accelerates the synthesis process, increases the specificity of the peptides produced, and enhances the overall efficiency. This has made reagents & consumables a key segment in the peptide synthesis market, offering customization, flexibility, and a wide range of products tailored for different research needs.
The equipment segment is projected to grow at the fastest rate during the forecast period. Advanced peptide synthesis equipment plays a critical role in ensuring precise and controlled amino acid sequencing, making it essential for the synthesis of peptides. Additionally, equipment is pivotal for drug lead optimization, structure-activity studies, and receptor binding studies. Technological advancements in peptide synthesis equipment have further accelerated growth in this segment, with new innovations designed to enhance synthesis speed and improve efficiency. A key development in this area was the launch of Vapourtec’s Peptide-Pilot, a solid-phase peptide synthesizer, in January 2024, which drastically reduces the drug development cycle from weeks to hours.
Liquid Phase Peptide Synthesis (LPPS) emerged as the leading technology in the peptide synthesis market in 2023. LPPS is a method where peptides are synthesized in a solution, offering several advantages over other synthesis techniques. This method facilitates the scalability of peptide production, minimizes the use of reagents and solvents, and makes the process more sustainable and environmentally friendly. Furthermore, LPPS allows for easy detection of side reactions, as products are purified after each step. These benefits have driven the widespread adoption of LPPS, cementing its position as the dominant technology in the market.
Hybrid technology is expected to grow at the highest CAGR during the forecast period. This technology combines two different synthesis methods, bringing together the best of both worlds: the precision and flexibility of chemical synthesis and the efficiency and sustainability of recombinant methods. Hybrid technology allows for the production of high-quality peptides at large scales and is particularly useful for synthesizing complex peptide structures and modifications. As researchers strive for more efficient and precise peptide production, hybrid technology is poised to be the future of peptide synthesis.
The therapeutics segment dominated the peptide synthesis market in 2023, and it is poised for continued growth. Peptide-based therapeutics are increasingly recognized for their ability to act as inhibitors or activators to treat a wide range of chronic disorders. The rising prevalence of chronic diseases has fueled the demand for peptide drugs, contributing to the growth of this segment. Peptide therapeutics offer numerous advantages over small molecule drugs, including superior target specificity, potency, and fewer side effects. The approval of 26 novel peptides by the US FDA between 2016 and 2022 further highlights the increasing investment and interest in peptide-based drugs, bolstering the segment’s expansion.
Peptide synthesis is also making significant strides in the diagnosis sector, with the diagnosis segment projected to be the fastest-growing in the coming years. Peptides are increasingly used in diagnostics, particularly for detecting and quantifying biomarkers in biological samples. Their high tissue penetration and non-immunogenic properties also make them ideal candidates for use in imaging techniques. The growing focus on early detection and accurate diagnosis of chronic disorders, coupled with favorable government policies, is expected to drive the expansion of the diagnosis segment.
In 2023, the pharmaceutical & biotechnology companies segment dominated the peptide synthesis market. These companies benefit from suitable capital investment, state-of-the-art infrastructure, and a pool of trained professionals who help drive innovation. Specialized labs and advanced tools for peptide synthesis further enhance the capabilities of these companies, allowing them to remain at the forefront of peptide research and development.
The CDMO/CRO segment is expected to grow rapidly during the forecast period. This growth is driven by the increasing number of contract-based peptide synthesis operations, which allow pharmaceutical and biotechnology companies to reduce development timelines and ensure high-quality results. CDMOs and CROs offer the necessary infrastructure and expertise to produce peptides efficiently, allowing companies to outsource their peptide synthesis needs while focusing on other areas of their business. This model is expected to continue driving the growth of the CDMO/CRO segment.
Recent innovations in the peptide synthesis field have further propelled the market’s growth. Notable advancements include the development of more efficient and sustainable methods for peptide synthesis. For instance, in July 2024, researchers from the University of Manchester unveiled a new technique for using ligase enzymes to synthesize peptide-based medicines for cancer treatment. This breakthrough promises to enhance the efficiency of peptide synthesis while reducing environmental impact.
Additionally, equipment manufacturers like Vapourtec have introduced systems such as the Peptide-Pilot, which can drastically reduce the time required for peptide synthesis, enabling faster drug development processes. These technological advancements are set to drive the peptide synthesis market’s future growth, offering enhanced efficiency, sustainability, and scalability.
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